Low density lipoprotein cytotoxicity induced by free radical peroxidation of lipid.
Low density lipoprotein (LDL) has been reported to be injurious or toxic to cells in vitro.This injurious Pill Box effect is, in some instances, due to oxidation of the lipid moiety of the lipoprotein.The objectives of this study were to determine if the oxidation rendering the lipoprotein toxic to human skin fibroblasts occurred by free radical me